A trans-historical introduction to the genre of science fiction. Focusing on novels, romances, short stories, and films, we explore relations between real and imagined worlds, the figure of the alien, and radical communities of humans and non-humans. Students consider how fictions of science formally and thematically expand possibilities of creation, transformation, and deformation. Our governing questions: how does escape into fictional realms alter contours of selfhood, while challenging structures including race, gender, and class? How does fiction shape ideas about power, policy, and change? Can vibrant worlds of scientific imagination model collaborations between the “two cultures” of “literature” and “science”?