Chemistry Department

Research

Summer Research Students 2013Have you ever wondered…

How particles affect climate?

How alcohol is toxic to the liver?

How laser light affects molecules?

How natural products are synthesized?

How green experiments are developed?

These and many other perplexing questions are being investigated every day at Hendrix College.
Explore below the diverse research projects being conducted in the Chemistry Department or
have a look at the research being conducted by our graduates .
 

Undergraduate Research Opportunities

Dr. Andres Caro:  Biological Chemistry

The Caro Research Group is interested in the biochemical mechanisms by which alcoholic beverages produce liver damage.  We use cell fractions (endoplasmic reticulum, mitochondria), cells (liver cells in culture), and experimental animals (mice), and analytical, biological, and cellular chemical techniques including HPLC, polarography, real time PCR, RT-PCR, ELISA, western blot, chemiluminescence, fluorimetry, spectrometry, flow cytometry, and fluorescence microscopy. 

Dr. Liz Gron: Analytical/InorganicChemistry

Dr. Gron’s research interests presently include environmental sampling of water and soil, development of undergraduate chemical educational materials: green analytical laboratories and scientific literacy, and the analysis of biologically relevant ions: hydrogen sulfide/garlic project    

Dr. Bill Gunderson:  Bioinorganic Chemistry

Dr. Bill Gunderson’s research is in the field of bioinorganic chemistry. Research in the Gunderson group has two aims: 1) determine the role of manganese in biomacromolecules, including enzymes and DNA structures, and 2) develop low-cost instrumentation for biochemical and biophysical studies. The first aim includes investigations of the enzyme, toxoflavin lyase, a Mn-containing enzyme that helps protect rice crops from bacterial infections. These enzymatic studies include enzyme kinetics and active site-structure studies using electron paramagnetic resonance (EPR) spectroscopy and other spectroscopic methods. Dr. Gunderson is also investigating the binding characteristics of Mn to DNA hairpins and three-way DNA junctions using EPR spectroscopy. The second aim includes developing spectroscopic techniques using 3D printing technology and Arduino microcontrollers.

Dr. David Hales: Physical Chemistry

Methods of mass spectrometry are used to study the energetics and dynamics of peptide folding and reactivity.  Specifically, this includes relative energies of different conformations, energy barriers to conformational changes, and thermodynamics of activation for certain reactions.  Ion mobility spectrometry-mass spectrometry (IMS-MS) separates and detects different conformations of the same molecule in the gas phase.  Ion trap mass spectrometry (ITMS) quantifies the ions in a sample by mass and charge.  Together, these methods allow us to follow processes in solution or in the gas phase.  This work is a collaboration with scientists at Indiana University, where the IMS-MS instrumentation is located.  ITMS experiments, data analysis, and modeling are performed at Hendrix.

Dr. Courtney Hatch: Analytical/Atmospheric Chemistry

The Hatch Research Group uses an integrative and multidisciplinary approach to study the effects of natural aerosols on the Earth system. We aim to better understand how natural aerosol influences atmospheric chemistry and climate. Currently, we are working on two ongoing research projects.  The first project combines theoretical and experimental results to predict the cloud condensation nuclei (CCN) activity of natural insoluble aerosols from water adsorption measurements on mineral dusts and volcanic ash using Fourier Transform Infrared (FT-IR) spectroscopy.  The second project aims to explore the chemical composition of atmospheric aerosols using a high-volume aerosol sampler for collection of particles, followed by chemical characterization using ion chromatography (IC) and gas chromatography/mass spectrometry (GC/MS)

Dr. Peter Kett: Physical Chemistry

In the Kett Research Group we are interested in studying surface and interfacial phenomena. Specifically we look at how solid surfaces interact with adsorbed molecules and how the adsorption process can be controlled through changes in ionic strength, pH, and surface charge. Currently the group is focused on developing a kinetic model for the formation of supported lipid bilayers (SLBs) on a silicon dioxide (SiO2) surface. SLBs are a class of model biological membrane in which a phospholipid bilayer is supported on a metal or non-metal surface. They are used as mimics of biological cell membranes as the large number of different molecules that are in a cell membrane makes it difficult to determine the structure, dynamics and interactions of each individual membrane component. Although SLBs can be formed on a number of different surfaces, they do not form on all surfaces and it is not usually possible to make an a priori prediction as to whether a particular combination of phospholipid concentration, surface, salt concentration, temperature, and solution pH will result in the formation of an SLB. By monitoring the real time formation of SLBs using a Quartz Crystal Microbalance (QCM) we are developing a mechanistic model that will allow us to determine how each of these experimental conditions affects the formation of SLBs.

Dr. Randall Kopper: Biological Chemistry

Coral snakes are a group of species with highly neurotoxic venom.  A key enzyme in coral snake venom is phospholipase A2 (PLA2), an esterolytic enzyme that hydrolyzes glycerophospholipids causing potent neurotoxicity, myonecrosis, and lipid membrane damage resulting in immobilization and death of those envenomated.  Our lab studies the PLA2 enzymes in the two most dangerous coral snake species in the U.S. to understand the evolution and activity of this polypeptide, and in particular how it varies from individual to individual based on gender, age, and geographic origin of the individual snake.

Dr. Mike Yanney: Organic Chemistry

Dr. Yanney’s research is in the area of supramolecular chemistry. Our aim is to design and synthesize robust molecular receptors that can form inclusion complexes with fullerenes with possible applications in separation science and organic photovoltaic devices (OPV). Our current strategy is employing 2,5-norbornadiene in the tether synthesis and using PAH units as pincers. The use of 2,5-norbornadiene leads to receptors that are rigid (RSC Advances 2016, 6, 50978-50984 and Angew. Chem, Int. Ed. 2015, 54, 11153-11156) and have the right topology to encapsulate fullerenes.