Following a successful homecoming celebration in March 1921, a group of graduates who lived in Conway met in December in the game room of Martin Hall and formed the Hendrix Alumni Club of Conway, the first group of its kind in the state. The members elected W.S. Cazort president and Mrs. Margaret Harwood Reynolds vice-president, and stated as their purpose the intent “to foster a spirit of good fellowship among all former students of Hendrix College and to afford its members an opportunity to inform themselves on the progress of their alma mater.” The next spring alumni groups organized similar clubs in Little Rock and Dallas, Texas.

By the late 1920s, Hendrix alumni constituted a distinguished group. In 1925 the College announced that Hendrix had graduated 360 ministers, 10 missionaries, six college presidents, 22 college professors, 60 school superintendents and more than 300 public school teachers.